Effect of Psychological Stress on Some Immunological Parameters Studied in Under Graduate Students
Keywords:
Examination stress, Immunological effect, Students
Abstract
The study deals the immunological effect before and during examination period on twenty undergraduate students with mean age 20(±1.7) years of both sexes. We calculating absolute numbers of neutrophils, lymphocytes and monocytes in blood, as well as the estimating of the effectiveness of phagocytic function of neutrophils by using NBT.on other hand serum level of IgG,IgM and C4 were estimated for those individuals. The results showed a significant increase in absolute numbers of monocytes compared with the period before examination and also a significant reduction in the absolute number of phagocytic cell compared with the period before examination, a significant increase in IgG, C4 serum level compared with the period before examination . The results suggest that there is a significant differences in some of non specific cellular and humoral factors and a significant increase in some of specific humoral factors in undergraduate students during examination period.Downloads
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References
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12. Kampen, A.H.; Tollersrud, T.; Larsen, S.; Roth, J.A.; Frank, D.E.; Lund, A. (2004). Repeatability of flow cytometric and classical measurement of phagocytosis and respiratory burst in bovine polymorphonuclear leukocytes. Vet Immunol Immunopathol 97, 105-114.
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19. Moraska, A.; Campisi, J.; Nguyen, K.T.; Maier, S.F.; Watkins, L.R.; Fleshner, M.(2002) Elevated IL-1beta contributes to antibody suppression produced by stress. J Appl Physiol 93:207-15.
20. Panasiuk, A.; Wysocka, J.; Maciorkowska, E.; Panasiuk, B.; Prokopowicz, D.; Zak, J.; Radomski, K.( 2005). Phagocytic and oxidative burst activity of neutrophils in the end stage of liver cirrhosis. World J Gastroenterol 11, 7661-7665.
21. Schleifer, S.J.; Keller, S.E.; Meyerson, A.T.(1984). Lymphocyte function in major depressive disorders. Arch Gen Psychiatry 41: 484–86.
22. Segal, A.B. ; Bruno, S. ; Forte, W.C.N.(2006) Immune function in acute stress. Allergol et Immunopathol 34(4):136-40.
23. Segerstrom, S.C.; Miller, G.E.; (2004). Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol. Bull .130, 601-630.
24. Shurin, M.R.; Zhou, D.; Kusnecov, A.; Rassnick, S.; Rabin, B.S.(1994) Effect of one or more footshocks on spleen and blood lymphocyte proliferation in rats. Brain Behav Immun. 8:57-65.
25. Simmons, A. and Statland, B.E. (1997). Hematology A Combined Theoretical And Technical Approach. 2nd ed. By Butterworth, Heinemann, U.S.A PP: 407-408.
26. Stites, D.P .; Terr, A.I.;Parslow, T.G.(1994) . Basic and clinical immunology . 8th ed.,lange medical publications ,U.S.A., pp:212-213.
27. Vidovic, A.; Vilibic, M.; Sabioncello, A.;Gotovac, K.; Rabatic, S.; Folnegovic-Smalc, V.; Dekaris, D.(2007) Circulating lymphocyte subsets, natural killer cell cytotoxicity, and components of hypothalamic-pituitary-adrenal axis in Croatian war veterans with posttraumatic stress disorder:crosssectional study.Croat Med J ;48:198-206.
28. Weinman, J.; Ebrecht, M.; Scott, S.; Walburn, J.; Dyson; M., (2008). Enhanced wound healing after emotional disclosure intervention. Br J Health Psychol 13, 95-102.
2. Anane, L.H.; Edwards, K.M.; Burns, V.E.; Zanten, J.J.; Drayson, M.T.; Bosch, J.A. (2010). Phenotypic characterization of gammadelta T cells mobilized in response to acute psychological stress. Brain Behav Immun 24, 608-614.
3. Burns, V.E.; Edwards, K.M.; Ring C.; Drayson, M.; Carroll, D.,( 2008). Complement cascade activation after an acute psychological stress task. Psychosom Med. 70, 387-396.
4. Davidson ,R.J.; Katbat- Zinn,J.; Rosenkranz,M.; Muller,D.; Santorelli,S.F. ; Urbanowski,F.; Harrington,A.;Bonus,K.;Sheridan,J.F.(2003) Alterations in brain and immune function produced by mindfulness meditation.Psychosom. Med.65:564-70.
5. Demetrikopoulos, M.K.; Siegel, A.; Schleifer, S.J.; Obedi, J.; Keller, S.E.(1994) Electrical stimulation of the dorsal midbrain periaqueduc-tal gray suppresses peripheral blood natural killer cell activity.Brain Behav Immun. 8:218-28.
6. Ellard, D.R.; Castle, P.C.; Mian, R.( 2001). The effect of a short-term mental stressor on neutrophil activation. International Journal of Psychophysiology 41, 93-100.
7. Endresen, I.M.; Relling, G.B.; Tonder, O.; Myking,O.;Walther, B.T.;Ursin, H.(1991)Brief uncontrollable stress and psychological parameters influence human plasma concentrations of IgM and complement component C3.Behav Med 17:167- 76.
8. Fleshner, M.; Hermann, J.; Lockwood, L.L.; Laudenslager, M.L.; Watkins, L.R.; Maier, S.F.(1995). Stressed rats fail to expand the CD45RC+CD4+(Th1-like) T cell subset in response to KLH: possible involvement of IFN-gamma. Brain Behav Immun. 9:101-12.
9. Glaser ,R.;Sheridan,J.F.;Malarkey,W.B.;MacCallum,R.C.;Kiecolt-Glaser ,J.K.(2000) Chronic stress modulates the immune response to a Pneumococcal pneumonia . Vaccine Psychosom Med.62:804-7.
10. Gloger, S.; Puente, J.; Arias, P.; Fischman, P.,; Caldumbide, I.; Gonzalez, R.(1997) Respuesta inmune diminuida ao estrés académico intenso: cambios de la proliferación linfocitaria en estudiantes de medicina. Rev Med Chil. 125:665-70.
11. Johnson, J.D.; Campisi, .J; Sharkey, C.M.; Kennedy, S.L.; Nickerson, M.; Greenwood, B.N.; Fleshner, M.(2005) Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines. Neuroscience 135:1295-307.
12. Kampen, A.H.; Tollersrud, T.; Larsen, S.; Roth, J.A.; Frank, D.E.; Lund, A. (2004). Repeatability of flow cytometric and classical measurement of phagocytosis and respiratory burst in bovine polymorphonuclear leukocytes. Vet Immunol Immunopathol 97, 105-114.
13. Kim, C.; Schinkel, C.; Fuchs, D.; Stadler, J.; Walz, A.; Zedler, S.(1995) Interleukin-13 effectively down-regulates the monocyte in-flammatory potential during traumatic stress. Arch Surg. 130:1330-6.
14. Lehmann, A.K.; Sornes, S.; Halstensen, A.( 2000). Phagocytosis: measurement by flow cytometry. J Immunol Methods 243, 229-242.
15. Leonard, B.E.; Song, C.(1996) Stress and the immune system in the etiology of anxiety and depression. Pharmacol Biochem Behav 54: 299–303.
16. lewis,S.M and Bain ,B.J.(2001): Dacie and lewis practical haematology. Harcount publishers limited ; 9th Edition.pp 320.
17. Mckenzie, S.B.(1996): Textbook of haematology.2ed., Williams and Wilkins, A waverly company .U.S.A.pp 605-607.
18. Miller, G.E.; Rohleder, N.; Stetler, C.; Kirschbaum, C.( 2005). Clinical depression and regulation of the inflammatory response during acute stress. Psychosom Med 67, 679-687.
19. Moraska, A.; Campisi, J.; Nguyen, K.T.; Maier, S.F.; Watkins, L.R.; Fleshner, M.(2002) Elevated IL-1beta contributes to antibody suppression produced by stress. J Appl Physiol 93:207-15.
20. Panasiuk, A.; Wysocka, J.; Maciorkowska, E.; Panasiuk, B.; Prokopowicz, D.; Zak, J.; Radomski, K.( 2005). Phagocytic and oxidative burst activity of neutrophils in the end stage of liver cirrhosis. World J Gastroenterol 11, 7661-7665.
21. Schleifer, S.J.; Keller, S.E.; Meyerson, A.T.(1984). Lymphocyte function in major depressive disorders. Arch Gen Psychiatry 41: 484–86.
22. Segal, A.B. ; Bruno, S. ; Forte, W.C.N.(2006) Immune function in acute stress. Allergol et Immunopathol 34(4):136-40.
23. Segerstrom, S.C.; Miller, G.E.; (2004). Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol. Bull .130, 601-630.
24. Shurin, M.R.; Zhou, D.; Kusnecov, A.; Rassnick, S.; Rabin, B.S.(1994) Effect of one or more footshocks on spleen and blood lymphocyte proliferation in rats. Brain Behav Immun. 8:57-65.
25. Simmons, A. and Statland, B.E. (1997). Hematology A Combined Theoretical And Technical Approach. 2nd ed. By Butterworth, Heinemann, U.S.A PP: 407-408.
26. Stites, D.P .; Terr, A.I.;Parslow, T.G.(1994) . Basic and clinical immunology . 8th ed.,lange medical publications ,U.S.A., pp:212-213.
27. Vidovic, A.; Vilibic, M.; Sabioncello, A.;Gotovac, K.; Rabatic, S.; Folnegovic-Smalc, V.; Dekaris, D.(2007) Circulating lymphocyte subsets, natural killer cell cytotoxicity, and components of hypothalamic-pituitary-adrenal axis in Croatian war veterans with posttraumatic stress disorder:crosssectional study.Croat Med J ;48:198-206.
28. Weinman, J.; Ebrecht, M.; Scott, S.; Walburn, J.; Dyson; M., (2008). Enhanced wound healing after emotional disclosure intervention. Br J Health Psychol 13, 95-102.
Published
2018-01-16
How to Cite
G. AL-Allaff, R. (2018). Effect of Psychological Stress on Some Immunological Parameters Studied in Under Graduate Students. Al-Qadisiyah Journal of Pure Science, 22(2), 226-233. Retrieved from https://journalsc.qu.edu.iq/index.php/JOPS/article/view/575
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