Effect of Rheumatoid arthritis on some blood criteria for patient in province Diwaniya
Keywords:
Rheumatoid arthritis, autoimmune disease, synovitis, blood parameter, ESR, PCV
Abstract
Rheumatoid arthritis (RA) is the most common autoimmune inflammatory disease in adults (1). Rheumatoid arthritis is also a chronic destructive inflammatory disease characterized by the accumulation and of an inflammatory infiltrate in the synovial membrane that leads to synovitis and the destruction of the joint architecture resulting in impaired its function 2. Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint swelling, joint tenderness, and destruction of synovial joints, leading to severe disability and premature mortality 3. The study includes thirteen (20 female and 10 male) patient with RA and (10 male and 20 female ) as the control attendants of Rheumatologic units in Al-Diwaniya Teaching Hospital of the period between January 2015 to December 2016 aged 18 to 74 years (median, 48.5 years) In the present study, significantly increased (p < 0.05) At WBC count, neutrophils, acidophil ESR, and significant decrease (p < 0.05). in Hb,RBCcount , PCV . These results suggest Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, primarily located in the synovial joints, leading to the destruction of the cartilage and bone as a result of the chronic disease activity that leads into elevation in WBC, Differential WBC, ESR and Low red blood cell count and PCV, Hb.Downloads
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References
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K; who, C.K, (2008). Estimates of the prevalence of arthritis and
Other rheumatic conditions in the United States: part I. Arthritis Rheum;58:15–25.
2. Jutley, G; Raza, K; Buckley, C.D. (2015 ). New insights into the pathogenesis rheumatoid of arthritis. Curr Opin Rheumatol. 27(3):249-55.
3. Isomaki, H. (1992). Long-term outcome of rheumatoid arthritis. Scand
J Rheumatol Suppl;95:3–8.
4. Erhardt, C.C; Mumford, P.A; Venables, P.J; Maini, R.N.( 1989). Factors
Predicting a poor life prognosis in rheumatoid arthritis: an eight year
Prospective study. Ann Rheum Dis; 48: 7–13.
5. Prior, P; Symmons, D.P; Scott, D.L;, Brown, R; Hawkins, C.F. (1984). Cause of
Death in rheumatoid arthritis. Br J Rheumatol; 23: 92–99
6. Mutru, O; Laakso, M; Isomaki, H; Koota, K.( 1989). Cardiovascular
Mortality in patients with rheumatoid arthritis. Cardiology;
76: 71–77.
7. Weis, G; Goodnough, L.( 2005). Anemia of chronic disease. N Engl J Med;352:1011-23.
8. Cash, J; Searsm, D. (1989). The anemia of chronic disease: spectrum
Of associated diseases in series of unselected hospitalized patients. Am J MED; 87 (6): 638-44.
9 . Hamilton, P.J. (1983). The hematology laboratory and the rheumatologist. Clin Rheum Dis.; 9 (1): 69.
10 Daniels, A; Tuhina, et al (2010). Rheumatoid Arthritis Classification Criteria. Journal of the American College of Rheumatology. (9): 2569–2581
11. Coles, E. H. (1980). Veterinary Clinical Pathology. 3ed Ed. W. B. Sanders. Co. Philadelphia. Pp: 190- 192.
12.Hillman, R.; S. And Ault, K. A.(2002). Hematology in Clinical Practice. 3rd ed., McGraw-Hill Co, New York.
13. Erikssen, G; Liestol, k.; Bjonhott; G. A. And Boaz, M. (2000). ''Erythrocyte sedimentation rate: a possible marker of atherosclerosis and a strong predictor of coronary heart disease mortality'' Eur. Heart. J. 21: 1614-1620
14 . Dace, J. V. And Lewis, S.M. (1984). Practical Haematology. 6th ed., Edinburgh, Churchill, Livingstone. Pp: 40- 55.
15 Sale, D.E. (1995). Medical Biostatistics and epidemiology examination and board review.first ed. Norwalk, Connecticut, Appleton and Lange:; 47, 88.
16 Weyand, C.M. (2000). New insights into the pathogenesis rheumatoid of arthritis. Rheumatology : 1:3-8.
17 Iain, B; McInnes, F.R. and Georg M.D.( 2011). The Pathogenesis of Rheumatoid Arthritis . The New England Journal of Medicine: MED 365;23
18. Lot, F, B;. Boval, D;. Weill, D. ; Kuntz and Walter, J..L. (1996). Blood monocyte activation in rheumatoid arthritis: increased monocyte adhesiveness, integrin expression, and cytokine release: Clin Exp Immunol; 106:13–19.
19. Carlos, T.M: Harlan, J.M.(1994). Leukocyte-endothelial adhesion molecules. Blood; 84:2068–101.
20. Antonius, S.(2006). Anemia of chronic disease in patients with rheumatoid arthritis: aspects of prevalence, outcome, diagnosis, and the effect of treatment on disease activity. The Journal of Rheumatology 33;1467-1468.
21. Jongen-L. ; M, Peeters, H.R.M, ; Backx, B, I.P, Touw,
Vreugdenhil, ; G, Swaak A.JG.( 1994). Recombinant human erythropoietin
Counteracts the inhibition of in vitro erythropoiesis by tumor necrosis factor alpha in patients with rheumatoid arthritis. Rheumatol Int;14: 109-13.
22. Peeters, H.R.M, ; Jongen, L. M, ; Vreugdenhil, G, Swaak, A.J.G.( 1996). Effect of recombinant human erythropoietin on anemia and disease activity in patients with rheumatoid arthritis and anemia of chronic disease: a randomized, placebo-controlled double blind 52-weeks clinical trial. Ann Rheum Dis;55:739-44.
Published
2018-01-15
How to Cite
M.K. AL-Mohammad, H. (2018). Effect of Rheumatoid arthritis on some blood criteria for patient in province Diwaniya. Al-Qadisiyah Journal of Pure Science, 22(2), 248-253. Retrieved from https://journalsc.qu.edu.iq/index.php/JOPS/article/view/573
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