Effecieny of Antioxidant defenses System in Burned Patients of Both Sexes with Second and Third Degrees of Burn

Abstract

Thermal burns are one of the most problem worldwide. Patients with burns are characterized by hypermetabolic state, increased vascular permeability, protein degradation, immune abnormalities, and oxidative stress. The present study was conducted to evaluate abnormalities occurring in antioxidants activities of burned patients of both sexes (males and females). One hundred fourteen subjects were recruited in this study of both sexes. Of those, 100 subjects (50 males and 50 females) were burned with thermal injuries. Burned males were subdivided according to severity of burn in to two groups; 25 burned males affected with second degree of burn and 25 burned males affected with third degree of burn. Similarly, the same classification was also applied with burned females. Fourteen healthy subjects (20 males and 20 females) were used as control group. All ages of the subjects were ranged between 20-40 years old.
Results obtained from this present study indicated that levels of catalase activity in all burned patients groups were significantly lower (p<0.05) than of healthy groups. Continuously, results of glutathione peroxidase activity were also significantly decreased (p<0.05) in all burned groups. Concentrations of reduced glutathione (GSH) showed a significant and insignificant fall in most burned patients (males and females).For measurement of lipid peroxidation, malondialdehyde (MDA) used in this study and served as indicator of lipid peroxidation and its values showed a progressive increase (p<0.05) in burned males and females when compared with healthy control group. The possible explanation of changes mentioned above may be attributed to progressive increase oxidative stress and release of inflammatory mediators which in-turn aggravate and worse physiological disturbances in burned patients.